In This Section
- Call for Board of Governors Nominations
- Deadline is February 15th
- The AES Celebrates Its E-Library Publications and Collections in September with FREE Offer for Members
- All members receive 25 free downloads in September 2015
- AES 2015 Election Results
- The results are in!
- Time to Vote: 2015 AES Elections
- Deadline was Friday, July 10th
Dietary Supplements for Protection of the Inner Ear
Colleen Le Prell
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. Although it was once thought that virtually all NIHL arose from mechanical damage to sensitive sensory cells in the inner ear, we now know that intense metabolic activity drives the formation of free radicals (short-lived, unstable, highly reactive clusters of atoms) in the inner ear. Studies in animals have clearly shown that free radicals formed during and after noise importantly contribute to NIHL, and many laboratories have demonstrated that free radical scavengers ("antioxidants") reduce NIHL in animal subjects. Investigators at multiple institutions have shown the combination of ß-carotene, vitamins C and E, and magnesium reduces NIHL in animals, and supporting data have been obtained in small Phase I/II clinical trial. Additional investigation is critical to now confirm potential utility of these agents in human subjects.